Active ingredients: Clenbuterol

Composition
1 ml: Clenbuterol hydrochloride 1 mcg. Excipients: sorbitol - 280 mg, glycerol - 200 mg, propylene glycol - 100 mg, sodium citrate dihydrate - 5.8 mg, citric acid monohydrate - 7 mg, methyl parahydroxybenzoate - 0.45 mg, propyl parahydroxybenzoate - 0.05 mg butyl parahydroxybenzoate - 0.05 mg, sodium benzoate - 1.2 mg, raspberry essence - 0.45 mg, ethanol 96% - 5 mg, purified water - up to 1 ml.

Pharmacological effect
Clenbuterol belongs to the group of selective β2-adrenergic agonists. Clenbuterol is a drug with a rapid bronchodilator effect. Its action is due to the specific stimulation of β2 - adrenergic receptors of smooth muscles. When bound with them, the enzyme adenylate cyclase is activated, which leads to an increase in the intracellular concentration of cyclic adenosine monophosphate and activation of protein kinase A, and deprives myosin of the ability to bind with actin, resulting in relaxation of the bronchi. Clenbuterol stimulates the cells of the bronchial mucosa and enhances expectoration. In the prescribed therapeutic doses, clenbuterol does not affect heart rate or blood pressure.

Pharmacokinetics
Absorption and distribution Clenbuterol is relatively quickly absorbed in the gastrointestinal tract. The connection with plasma proteins is 89-98%. Metabolism and excretion Biological T1 / 2 is 3.5 hours. It is excreted mainly through the kidneys in the form of sulfonated derivatives.
Indications
- bronchial asthma; - chronic obstructive pulmonary disease (COPD).

Contraindications
- thyrotoxicosis; - hypertrophic obstructive cardiomyopathy; - angle-closure glaucoma; - pheochromocytoma; - tachyarrhythmia; - myocardial infarction (acute period); - pregnancy (I and III trimester); - lactation period; - children under 6 years of age; - hypersensitivity to active or to any of the excipients.

Precautionary measures
Do not exceed the recommended doses. With caution in the following cases: immediately after a myocardial infarction, with hepatic and renal failure, heart rhythm disturbances, myocarditis, mitral valve defects, hypokalemia, unstable or uncompensated diabetes.

Application during pregnancy and lactation: recommendation for UK patients
Clenbuterol syrup is not used during the first three months of pregnancy, as well as during the last trimester due to the suppressive effect on labor. Clenbuterol syrup is not used during breastfeeding. In the second trimester of pregnancy and during lactation, the use of an inhaled form of clenbuterol is recommended. If you want to buy clenbuterol online without prescription you can look at clenbuterol uk roids as best supplier of anabolic steroids in the UK.

Method of administration and dosage
The drug is taken orally. The daily dose for children from 6 to 12 years old (body weight 22-35 kg) is 15 μg (for 2 doses). Adults and children over 12 years old: 2 times a day, 10-20 μg. Maintenance dose - 2 times 10 mcg. The duration of the course of treatment with Clenbuterol is 2-3 days, until the acute symptoms of the disease are removed. The duration of maintenance therapy should not exceed 7 days. The decision on treatment for more than seven days is made by the attending UK physician.

Side effects
Muscular system: minor muscle tremor CNS: anxiety, headache Cardiovascular system: decrease or increase in blood pressure, tachycardia, angina pain, ventricular premature beats Skin and mucous membranes: skin rash, facial edema, urticaria Blood system: thrombocytopenia , hypoglycemia. Gastrointestinal tract: gastritis, diarrhea, dry mouth, nausea. Urogenital system: urinary disturbance. The described adverse reactions disappear without stopping treatment, 1-2 weeks after its start.

Overdose
Symptoms: tremors of the fingers, increased sweating, headache, tachycardia. In especially severe cases of overdose of this drug, collapse, convulsions and coma are possible. Urgent measures: in all cases of overdose, the intake of clenbuterol is stopped. Gastric lavage is performed, activated carbon is injected, forced diuresis is performed and symptomatic treatment is started. The use of clenbuterol syrup in doses exceeding the recommended ones may worsen the course of bronchial asthma. In such cases, immediate consultation with a doctor in the UK and, if necessary, hospitalization is necessary.